O20. Hypoxic Regulation of Epigenetic Modifications During Disease Progression in Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
Epigenetic modifications in rheumatoid arthritis
Over the last decades, genetic factors for rheumatoid diseases like the HLA haplotypes have been studied extensively. However, during the past years of research, it has become more and more evident that the influence of epigenetic processes on the development of rheumatic diseases is probably as strong as the genetic background of a patient. Epigenetic processes are heritable changes in gene ex...
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Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they ar...
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Background: Bone mineral density (BMD) changes during the course of rheumatoid arthritis (RA). The present study was designed to investigate the status of BMD in patients with RA treated with anti-rheumatic drugs. Methods: BMD at the femoral neck (FN-BMD) and lumbar spine (LS-BMD) were measured by dual energy x-ray absorptiometry (DXA) method using Norland densitometer. Disease activity (DA) wa...
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Radiographic progression is an important outcome measure in clinical trials and observational studies with patients with rheuamtoid arthritis. In this article we describe several aspects of measuring radiographic progression. We introduce the scoring method, discuss scoring methodology and issues regarding reliability of scoring, describe the relation between disease activity, radiographic prog...
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Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs). Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA). The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational modifications (PTM) relevant to RA have since been des...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2014
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/keu089.002